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Located in Worcester, Massachusetts, the UMass Cancer Center is committed to providing exceptional patient care, conducting cutting-edge research at the highest level, offering excellence in education and training, and serving as an educational resource and advocate for the Central Massachusetts community.
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Patients

Expert Cancer Care in Central Massachusetts

We offer comprehensive cancer care for all childhood and adult cancers, combining state-of-the-art treatments with compassionate support for patients and their families.
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Research
Research

Cutting-Edge Cancer Research

We carry out front-line research in basic, translational, clinical and population-based discovery to find newer, better methods for the prevention, detection, diagnosis, and treatment of cancer.
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Education

World Class Medical and Scientific Education

The UMass Cancer Center is dedicated to training the next generation of cancer researchers, clinicians and physician-scientists.
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Michael Green Memorial
Michael Green Memorial

UMass Chan lost one of its greats when Michael R. Green, MD, PhD, passed away unexpectedly in February 2023. We've established these web pages in his memory so our visitors can take a few minutes, from time to time, to peruse and remember him.

Donate to the The Michael R. Green, MD, PhD, Award in Graduate Research:

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Additional Resources

Karl Simin, PhD

Associate Professor, Department of Molecular, Cell and Cancer Biology; Director, Cancer Center Tissue and Tumor Bank, UMass Chan Medical School

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Karl Simin, PhD

Research Focus - Molecular Pathways of Cancer Malignancy

Study of breast tumor biology in the context of pRb, p53, and Brca1 loss
Characterization of transcriptomic signatures of breast atypia
Use of transgenic mouse models of triple-negative breast cancer
Elucidation of Dkk and Wnt/β-catenin signaling in cancer
Use of patient-derived xenograft mouse models from the UMass Cancer Avatar Institute

Representative Publication

Johnson JP, Kumar P, Koulnis M, Patel M, Simin K. Crucial and novel cancer drivers in a mouse model of triple-negative breast cancer. Cancer Genomics Proteomics. 2014;11(3):115-126.

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