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Joae Wu, PhD

Research Focus - Epigenetic Regulation of Tumor Metastasis, Cancer Metabolism, Drug Resistance and Cancer Stem Cells in Neuroblastoma

  • Protein arginine methyltransferase 5 (PRMT5) mediating tumor metastasis
  • SMARCA4/PRMT5 regulating the maintenance cancer stem cell population
  • SWI/SNF and co-factors rewiring cancer metabolism in tumor microenvironment
  • SMARCA4/PRMT5 modulating drug resistance

Representative Publication

Wu Q, Madany P, Dobson JR, et al. The BRG1 chromatic remodeling enzyme links cancer cell metabolism and proliferation. Oncotarget. 2016;7(25):38270-38281.

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In the News

Getting Results…
  • Summer undergraduate research students highlight collaboration, diversity at UMass Chan

    Summer undergraduate research students highlight collaboration, diversity at UMass Chan

    Forty future health and science professionals spent the summer immersed in UMass Chan’s cutting-edge laboratories.

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  • Jason Shohet receives second Hyundai Hope on Wheels grant

    Jason Shohet receives second Hyundai Hope on Wheels grant

    Hyundai Hope on Wheels has awarded Jason Shohet, MD, PhD, a second $300,000 Scholar Hope Grant to continue his research on neuroblastoma, a deadly cancer in children that affects the peripheral nervous system.

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