Jianhan Chen, PhD
Research Focus - Sequence-Structure-Function-Disease Relationship of Intrinsically Disordered Proteins in Cancer
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Combine simulation and experiment to understand the molecular basis of function and regulation of intrinsically disordered proteins (IDPs) involved in cancer
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Exploit the tumor suppressor p53 as an important paradigm for studying the sequence-structure-function relationship of IDPs in cancer
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Develop strategies to target IDPs through dynamics interactions with small molecules
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Develop multi-scale modeling and simulation methods for studying IDP structure and interaction
Representative Publication
Ganguly D, Chen J. Modulation of the disordered conformational ensembles of the p53 transactivation domain by cancer-associated mutations. PLoS Comput Biol. 2015;11(4):e1004247.