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Craig Ceol, PhD

Research Focus - Melanoma Progression and Therapy

  • Identifying genes involved in melanoma progression
  • Determining the mechanistic basis of oncogenes and tumor suppressors in melanoma initiation
  • Defining the intersection of melanocyte stem cell biology and melanoma progression
  • Developing novel therapies to complement existing targeted immunotherapies

Representative Publication

Venkatesan AM, Vyas R, Gramann AK, et al. Ligand-activated BMP signaling inhibits cell differentiation and death to promote melanoma. J Clin Invest. 2018;128(1):294-308.

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More Publications

Inventions

Targeting GDF6 and BMP Signaling for Anti-cancer Therapy. UMMS15-21; Patent Pending.

A method of treating a melanoma in a subject, comprising administering to a subject an effective amount of an inhibitor of GDF6/BMP13 activity.

  • Technology: Small Molecules
  • Applications: Cancer, Myeloma

In the News

Getting Results…
  • UMass Chan BRIDGE Fund invests nearly $2M in 13 faculty projects

    UMass Chan BRIDGE Fund invests nearly $2M in 13 faculty projects

    The BRIDGE Fund supports critical research milestones for inventions and discoveries that have high potential to change the course of disease and continues to grow, increasing from approximately $1 million per year in 2019 to $3 million in 2024.

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  • Zebrafish helpful models to study skin conditions like vitiligo and melanoma, UMass Chan scientist writes

    Zebrafish helpful models to study skin conditions like vitiligo and melanoma, UMass Chan scientist writes

    Craig Ceol, PhD, and his team recently discovered a new way in which melanocytes, a small subset of epidermal cells, regenerate. Dr. Ceol explains why zebrafish are good models to study melanocytes in this piece for The Conversation.

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  • Craig Ceol receives NIH grant to study melanocyte regeneration

    Craig Ceol receives NIH grant to study melanocyte regeneration

    Craig Ceol, PhD, has received a grant from the National Institute of Arthritis and Musculoskeletal and Skin Diseases to fund research on cellular and molecular regulators of melanocyte regeneration using zebrafish as a model.

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  • U.S. Army grant advances UMMS studies targeting key melanoma protein

    U.S. Army grant advances UMMS studies targeting key melanoma protein

    The U.S. Department of Defense awarded a team of researchers led by Craig J. Ceol, PhD, a $963,903 three-year grant to test potential approaches to killing metastatic melanoma tumors.

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