Barbara Osborne, PhD
Research Focus - Signaling Pathways and T Cell Activation
- The role of Notch signaling in T cell activation
- Gamma secretase modulation of T cell activation
- Mechanisms of checkpoint inhibition of T cells
- 3D Spheroid models of cancer for studies of immune checkpoint blockade in various tumor models
- Delivery of checkpoint inhibitors using rAAV
Representative Publication
Hossain F, Majumder S, Ucar DA, et al. Notch signaling in myeloid cells as a regulator of tumor immune responses. Front Immunol. 2018;9:1288.