Search the Cancer Center site

Search the Cancer Center site

Home
About
About

Located in Worcester, Massachusetts, the UMass Cancer Center is committed to providing exceptional patient care, conducting cutting-edge research at the highest level, offering excellence in education and training, and serving as an educational resource and advocate for the Central Massachusetts community.
Patients
Patients

Expert Cancer Care in Central Massachusetts

We offer comprehensive cancer care for all childhood and adult cancers, combining state-of-the-art treatments with compassionate support for patients and their families.
Clinicians
Research
Research

Cutting-Edge Cancer Research

We carry out front-line research in basic, translational, clinical and population-based discovery to find newer, better methods for the prevention, detection, diagnosis, and treatment of cancer.
Education
Education

World Class Medical and Scientific Education

The UMass Cancer Center is dedicated to training the next generation of cancer researchers, clinicians and physician-scientists.
Outreach
Michael Green Memorial
Michael Green Memorial

UMass Chan lost one of its greats when Michael R. Green, MD, PhD, passed away unexpectedly in February 2023. We've established these web pages in his memory so our visitors can take a few minutes, from time to time, to peruse and remember him.

Donate to the The Michael R. Green, MD, PhD, Award in Graduate Research:

Donate

Additional Resources

Andrew H. Fischer, MD

Professor, Department of Pathology; Director, Cytopathology, UMass Chan Medical School

Website

Page Menu

Andrew H. Fischer, MD

Research Focus - Structural Basis of Diagnostic Nuclear Morphologic Changes in Cancer

Development of the concept that a significant subset of structural changes are induced, in a cell type-specific manner, by the oncogenes that are active in particular tumors
Study of nuclear lamina and nuclear positioning changes induced by B-RAF and RET and TRK tyrosine kinases in human papillary thyroid carcinoma (a subset of diagnostic structural changes induced by cancer genes that have relatively rapid dynamics after oncogene expression)
Development of a robust method for visualizing human tissue samples at high resolution with two-photon microscopy in time lapse (a method that enables gene editing/expression for mechanistic studies), in order to learn about the structural basis and functional significance of oncogene-induced changes in nuclear morphology

Representative Publication

Fischer AH, Zhao C, Li QK, et al. The cytologic criteria of malignancy. J Cellular Biochem. 2010;110(4):795-811.

Read Publication

More Publications