Research Interest: The Ali team develops antiviral drug candidates using structure-based design strategies to avoid resistance.

Broader Impact: HIV, HCV, cancer, influenza, dengue, COVID-19

Office Location: LRB 840
Lab Location: LRB 860 C
Phone: 508-856-8873

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Research Interest: The Han lab uses a multidisciplinary approach to develop nanomaterials for use in chemistry and biology research and in drug delivery.

Office Location: LRB 806
Lab Location: LRB 870 U
Phone: 508-856-3297


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Research Interest: The Kobertz Lab develops new tools to study the roles of glycosylation in ion channel localization and function. 

Broader Impact: Cardiac arrythmias, hearing loss

Office Location: LRB 804
Lab Location: LRB 840 C
Phone: 508-856-8861

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Research Interest: The Miller Lab develops optical imaging probes, ranging from the design of new fluorescent molecules to engineered luciferins and luciferases for in vivo bioluminescence imaging. 

Key Words: bioluminescence, fluorescence, near-infrared, imaging, probes, chemical biology 

Research Tools: fluorescence microscopy, synthetic organic chemistry, bioluminescence imaging, AAV transduction, mouse models, mammalian cell culture, spectrophotometry, NMR, mammalian cell culture, M. musculus (mouse)

Broader Impact: optical probes are broadly applicable to study many different diseases

he/him/his
Office Location: LRB 805
Lab Location: LRB 870 X
Phone: 508-856-8865

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Research Interest: The Royer lab uses their expertise in X-Ray Crystallography to study how the assembly of macromolecules regulates biological function.
 
Key Words: Structural Biology, X-ray Crystallography, Protein Assembly and regulation.

Research Tools: X-Ray Crystallography

Broader Impact: Cancer

he/him/his
Office Location: LRB 921
Lab Location: LRB 970 G, W
Phone: 508-856-6912

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Research Interest: The Schiffer Lab studies the molecular basis for drug resistance and has developed a new paradigm for avoiding drug resistance when targeting enzymes in structure-based drug design.

Research Tools:  protein crystallography, CryoEM/CryoET, molecular dynamics simulations, homology modeling, enzymatic assays and medicinal chemistry,

Broader Impact: RNA Viruses (HIV, HTLV, Influenza, Coronaviruses, Enteroviruses, Flaviviruses) and Cancer

Office Location: LRB 928
Lab Location: LRB 840 D; 860 C; 960 E; 970 C, D, L, M
Phone: 508-856-8008
  
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Research Interest: The Thompson lab is a leader in the field of chemical biology and exploits these techniques to study biomedically-important enzymes and proteins including the Protein Arginine Deiminases, STING and SARM1.

Key Words: Drug discovery, deimination, autoimmunity, rheumatoid arthritis, citrullination, enzymology

Research Tools: Enzymology, medicinal chemistry, chemical biology, proteomics, inhibitor design

Broader Impact: rheumatoid arthritis, sepsis, lupus, STING-associated vasculopathy in infancy, ALS, peripheral neuropathies, cancer.

Office Location: LRB 825
Lab Location: LRB 860 B, C, E
Phone: 508-856-8492
 
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Research Interest: The Yu Lab builds multiplexed, intelligent proteomics platforms to systematically understand protein function in health and disease and to advance therapeutic development. 

Key Words: Multiplexed proteomics, mass spectrometry, post-translational modification, bioinformatics, chemical biology, cell signaling, systems biology, drug discovery 

Research Tools: Mass spectrometry, mammalian cell culture, mouse model

Broader Impact: Drug resistance, cancer, aging

Office Location: LRB 815
Lab Location: LRB 870 D, E
Phone: 508-856-2174
  
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